Harnessing bioactive compounds from Cannabis sativa residue to improve rumen fermentation and reduce methane production: in silico, in vitro, and in situ nylon bag studies (2025)

The inhibition of methyl-coenzyme M reductase (MCR) effectively suppresses ruminal methanogen activity, thereby mitigating enteric methane emissions in ruminants. However, the development of highly specific and environmentally sustainable inhibitors remains a significant challenge. This study aimed