Cannabigerol reverses mechanical allodynia through α 2A ‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy (2025)

CBG reverses mechanical allodynia in CIPN by reducing presynaptic neurotransmission at VPL-to-S1HL synapses through the activation of α_2A-adrenoceptors. These findings identify a thalamocortical circuit mechanism and a cannabinoid-sensitive target for neuropathic pain treatment.