Chemometric Optimization of BF 3 ·OEt 2 ‐Mediated Cyclization of Cannabidiol to Rare Δ⁴‐ and Iso ‐THC Isomers (2025)

The acid-catalyzed conversion of cannabidiol (CBD) to tetrahydrocannabinol and iso-tetrahydrocannabinol derivatives is a well-established synthetic strategy. However, since the reaction outcome is strongly dependent on the conditions, a careful investigation is always required to achieve the optimal